Mark J. Snider
Robert E. Wilson Professor of Chemistry; Program Co-Chair of Biochemistry and Molecular Biology (On Leave Spring 2023)
Phone: 330-263-2391
Office: Williams 194
CV/Resume: Download
Degrees
- B.A. Capital University, Chemistry 1997
- Ph.D. University of North Carolina at Chapel Hill, Biochemistry & Biophysics 2001
Areas of Interest
- Mechanistic and structural enzymology of aerobic nicotinic acid (Vitamin B3) catabolism.
- Determining the genes and mechanisms of degradation of antidepressants by bacteria in the environment.
- Functional characterization of novel phosphagen kinases, with the goal of discerning the evolution of substrate specificity, cooperative substrate binding and quaternary structure.
Courses Taught
- CHEM 101: Chemistry and the World in Which We Live
- CHEM 111: General Chemistry I
- CHEM 112: General Chemistry II
- CHEM 399: Biophysical Chemistry
- BCMB 303: Techniques in Biochemistry & Molecular Biology
- BCMB 331: Principles of Biochemistry
- BCMB 332: Biochemistry of Metabolism
- BCMB 401: Introduction to Independent Study
- IDPT 101: First Year Seminars in Critical Inquiry
Independent Study Advising
- Laura Sherer: Biophysical characterization of the cofactors in the putative NicAB complex from Bacillus niacini.
- Tsun Ki Jerrick To: Characterizing the genetic determinants of the nicotinic acid degradation pathway in Bacillus niacini.
- Manish Aryal: Evolution of negative cooperativity in phosphagen kinases
Publications
- D. Fraga., K. Stock*, M. Aryal*, C. Demoll*, L. Fannin*, and M. J. Snider (2019) Bacterial arginine kinases have a highly skewed distribution within the Proteobacteria. Comparative Biochemistry and Physiology – Part B 233, 60-71.
- K. D. Nakamoto*, S. W. Perkins*, R. G. Campbell*, M. R. Bauerle*, T. G. Gerwig*, S. Gerislioglu, C. Wesdemiotis, M. A. Anderson, K. A. Hicks and M. J. Snider (2019); Mechanism of 6-hydroxynicotinate 3-monoxygenase, a flavin-dependent decarboxylative hydroxylase involved in aerobic nicotinic acid degradation; Biochemistry58, 1751-1763.
- Katherine A. Hicks, Meigan E. Yuen, Wei Feng Zhen, Tyler J. Gerwig*, Ryan W. Story*, Megan Kopp, Mark J. Snider (2016) Structural and biochemical characterization of 6-hydroxynicotinic acid 3-monooxygenase, a novel decarboxylative hydroxylase involved in aerobic nicotinate degradation. Biochemistry 55, 3432-3446.
- D. Fraga, M. Aryal*, J. E. Hall*, E. Rae*, and M. Snider (2015) Characterization of the arginine kinase isoforms in Caenorhabditis elegans. Comparative Physiology and Biochemistry; Part B: Biochemistry & Molecular Biology 187; 85-101.
- Z. H. Harvey* and M. J. Snider (2014) Draft genome of the nicotinate-metablizing soil bacterium Bacillus niacini (DSM 2923). Genome Announc. 2 (6) e01251-14.
- A. Palmer*, B. Begress*, J. Van Houten*, M. J. Snider, and D. Fraga (2013) Characterization of a putative oomycete taurocyamine kinase: Implications for the evolution of the phosphagen kinase family. Comparative Physiology and Biochemistry; Part B: Biochemistry & Molecular Biology, 166; 173-181.
- G. K. Schroeder, L. Zhou, M. J. Snider, X. Chen, and R. Wolfenden (2012) Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: mass spectrometric evidence for the presence of a trapped water molecule. Biochemistry 51, 6476-6486.
- J. Bragg, A. Rajkovic*, C. Anderson, R. Curtis, J. V-Houten*, B. Bergres*, C. Naples*, M. Snider, D. Fraga, and M. Singer (2012) Identification and characterization of an arginine kinase from Myxococcus xanthus required from fruiting body formation and cell differentiation; J. Bacteriology 194, 2668-2676.
- V. A. Kincaid*, E. D. Sullivan*, R. D. Klein*, J. W. Noel*, R. S. Rowlett, M. J. Snider (2012) Structure and catalytic mechanism of nicotinate (vitamin B3) degradative enzyme maleamate amidohydrolase from BrodetellaBronchiseptica RB50; Biochemistry 51, 545-554.
Awards
- National Science Foundation (2018-present), Molecular Biophysics Program RUI: Collaborative Research: Enzymology of Bacterial Nicotinic Acid Catabolism by Mark Snider (PI), Katherine Hicks (PI, SUNY Cortland) $ 551,536.
- National Science Foundation (2016-2019), Major Research Instrumentation Program Acquisition of an NMR Spectrometer to Sustain Excellence in Undergraduate Research with Paul Bonvallet (PI), Judith Amburgey-Peters, Spring Knapp and Sarah Sobeck
- Research Corporation for Science Advancement: Multi-Investigator Cottrell College Science Award Program (2012-2014), “Bacterial Degradation of Pharmaceuticals and Personal Care Products During Waste Water Treatment” with Stephanie Strand (Biology) and Melissa Schultz (Chemistry).
- National Science Foundation (2008-2011), “Acquisition of an LC/MS/MS to Enhance Undergraduate Research and Teaching” with Melissa Schultz and Paul Edmiston (Chemistry).
- National Science Foundation (2006-2009), “Acquisition of an Isothermal Titration Calorimeter” with Paul Bonvallet (Chemistry) and Don Jacobs (Physics).
- National Science Foundation (2004-2007), “RUI: Comparative Structure – Function Analysis of Phosphagen Kinases” with Paul Edmiston and Dean Fraga (Biology).