• B.A. Capital University, Chemistry 1997
  • Ph.D. University of North Carolina at Chapel Hill, Biochemistry & Biophysics 2001
Areas of Interest
  • Mechanistic and structural enzymology of bacterial degradation of nicotinic acid.
  • Using stopped-flow spectrophotometry to investigate kinetic mechanisms of flavin monooxygenases.
  • Functional characterization of novel phosphagen kinases, with the goal of discerning the evolution of substrate specificity, cooperative substrate binding and quaternary structure.
Courses Taught
  • CHEM 101: Chemistry and the World in Which We Live
  • CHEM 111: General Chemistry I
  • CHEM 112: General Chemistry II
  • CHEM 399: Biophysical Chemistry
  • BCMB 303: Techniques in Biochemistry & Molecular Biology
  • BCMB 331: Principles of Biochemistry
  • BCMB 332: Biochemistry of Metabolism
  • BCMB 401: Introduction to Independent Study
  • IDPT 101: First Year Seminars in Critical Inquiry
Independent Study Advising
  • Takoda Zuehlke (2023) BCMB: Identification of a putative binding mechanism for the reducing substrate of 6-hydroxynicotinate 3-monooxygenase
  • May Z. Hlaing(2022) BCMB: Investigating substrate specificity for 6-hydroxynicotinate-3-monooxygenase (NicC) with alternative substrates: consequences to catalysis of replacing or removing the ring nitrogen
  • Robert Beal (2022) BCMB: Role of tight binding in negative cooperativity in the dimeric mitochondrial taurocyamine kinase from Arenicola brasiliensis
  • Z. R. Turlington; S. V. Ferreira de Macedo; K. Perry; S. L. Belsky*; J. A. Faust; M. J. Snider, K. A. Hicks (2023) Ligand bound structure of a 6‐hydroxynicotinic acid 3‐monooxygenase provides mechanistic insights; Accepted for publication in Archives in Biochemistry & Biophysics
  • S. W. Perkins*, M. Z. Hlaing*, K. A. Hicks, L. Rajakovich, M. J. Snider (2023) Mechanism of the multi-step catalytic cycle of 6-hydroxynicotinate 3-monooxygenase revealed by global kinetic analysis; Biochemistry 62; 1553-1567.
  • P. Piper*, B. Begres*, M. Snider, D. Fraga (2020) Two cryptosporidia species encode active creatine kinases that are not seen in other Apicomplexa species; Comparative Biochemistry and Physiology – Part B 246, 110459.
  • K. D. Nakamoto*, S. W. Perkins*, R. G. Campbell*, M. R. Bauerle*, T. G. Gerwig*, S. Gerislioglu, C. Wesdemiotis, M. A. Anderson, K. A. Hicks, M. J. Snider (2019) Mechanism of 6-hydroxynicotinate 3-monoxygenase, a flavin-dependent decarboxylative hydroxylase involved in aerobic nicotinic acid degradation. Biochemistry 58; 1751-1763.
  • K. A. Hicks, M. E. Yuen, W.- F. Zhen, T. J. Gerwig*, R. W. Story*, M. Kopp, M. J. Snider (2016) Structural and biochemical characterization of 6-hydroxynicotinic acid 3-monooxygenase, a novel decarboxylative hydroxylase involved in aerobic nicotinate degradation. Biochemistry 55, 3432–3446.
  • Mark J. Snider and Katherine A. Hicks (2024) Novel enzymology of nicotinic acid degradation in Bacillus niacini. 28th Enzyme Mechanism Conference, Naples, FL, January 2024.
  • Mark J. Snider, Jack Redick, May Hlaing and Lauren Rajakovich (2023) Probing substrate specificity in the class A flavin enzyme 6-hydroxynicotinate 3-monooxygenase; Midwest Enzyme Chemistry Conference, Northwestern University, Evanston, IL, September 2023
  • National Science Foundation (2018-present), Molecular Biophysics Program RUI: Collaborative Research:  Enzymology of Bacterial Nicotinic Acid Catabolism by Mark Snider (PI), Katherine Hicks (PI, SUNY Cortland) $ 551,536.
  • National Science Foundation (2016-2019), Major Research Instrumentation Program Acquisition of an NMR Spectrometer to Sustain Excellence in Undergraduate Research with Paul Bonvallet (PI), Judith Amburgey-Peters, Spring Knapp and Sarah Sobeck
  • Research Corporation for Science Advancement: Multi-Investigator Cottrell College Science Award Program (2012-2014), “Bacterial Degradation of Pharmaceuticals and Personal Care Products During Waste Water Treatment” with Stephanie Strand (Biology) and Melissa Schultz (Chemistry).
  • National Science Foundation (2008-2011), “Acquisition of an LC/MS/MS to Enhance Undergraduate Research and Teaching” with Melissa Schultz and Paul Edmiston (Chemistry).
  • National Science Foundation (2006-2009), “Acquisition of an Isothermal Titration Calorimeter” with Paul Bonvallet (Chemistry) and Don Jacobs (Physics).
  • National Science Foundation (2004-2007), “RUI: Comparative Structure – Function Analysis of Phosphagen Kinases” with Paul Edmiston and Dean Fraga (Biology).