Synthesis and Photophysical Evaluation of Porphyrin-Natural Product Hybrids for Use in Photodynamic Therapy

Holly McAnlis head shot

Name: Holly McAnlis
Major: Chemistry
Advisor: Dr. Paul Bonvallet

Photodynamic therapy is a cancer treatment that involves dosing a patient with a drug molecule called a photosensitizer, which can be excited with light and kill cancerous cells by producing a type of reactive oxygen species called singlet oxygen. Photosensitizer development is a promising route to treat various cancers and target inoperable tumors. Therefore, two porphyrin-based photosensitizers, TPP-Sesamol and TPP-Zingerone, were synthesized and characterized by mass spectrometry, NMR, and IR spectroscopy. The lifetimes of the singlet and triplet excited states were determined by the Turro Group at the Ohio State University using nanosecond transient absorption spectroscopy. The singlet oxygen quantum yield values indicated that half of the excited electrons in the triplet state formed singlet oxygen. This work can lead to optimizing new photosensitizers for photodynamic therapy.

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Posted in Comments Enabled, Independent Study, Symposium 2022.

7 responses to “Synthesis and Photophysical Evaluation of Porphyrin-Natural Product Hybrids for Use in Photodynamic Therapy”

  1. Nina Catalfo says:

    Great work this year, Holly! You work harder than anyone I know and it shows in the quality of your work.

  2. Holly McAnlis says:

    Thank you, Nina! I really enjoyed working with you this year.

  3. Jennifer Faust says:

    What a great combination of physical chemistry, medicinal chemistry, and organic chemistry!

  4. Christine McAnlis says:

    What an incredible IS subject! You have learned and accomplished so much throughout your four years at the College of Wooster. Your IS demonstrates the depth and breadth of knowledge you’ve gained and illustrates the solid foundation you have. Congratulations!

  5. Holly McAnlis says:

    Thank you Dr. Faust!

  6. Holly McAnlis says:

    Thank you Mom! Couldn’t have done it without you 🙂

  7. Megan Zins says:

    Holly, you have done so much over the past two years in preparation and execution of this project and you should be extremely proud of yourself for that! Amazing job!