Synthesis and Photophysical Evaluation of Porphyrin-Natural Product Hybrids for Use in Photodynamic Therapy
Name: Holly McAnlis
Advisor: Dr. Paul Bonvallet
Photodynamic therapy is a cancer treatment that involves dosing a patient with a drug molecule called a photosensitizer, which can be excited with light and kill cancerous cells by producing a type of reactive oxygen species called singlet oxygen. Photosensitizer development is a promising route to treat various cancers and target inoperable tumors. Therefore, two porphyrin-based photosensitizers, TPP-Sesamol and TPP-Zingerone, were synthesized and characterized by mass spectrometry, NMR, and IR spectroscopy. The lifetimes of the singlet and triplet excited states were determined by the Turro Group at the Ohio State University using nanosecond transient absorption spectroscopy. The singlet oxygen quantum yield values indicated that half of the excited electrons in the triplet state formed singlet oxygen. This work can lead to optimizing new photosensitizers for photodynamic therapy.
7 responses to “Synthesis and Photophysical Evaluation of Porphyrin-Natural Product Hybrids for Use in Photodynamic Therapy”
Related Areas of Study
Access to labs, research opportunities, and small classes give chemistry majors lots of options after graduation.Major Minor